Vallette J, Lansac J, Grimaud J A, Cardon J P, Rochet Y
J Gynecol Obstet Biol Reprod (Paris). 1976 Jun;5(4):495-512.
The authors present a standard for interpreting the histopathology of testicular biopsies carried out during the framework of investigation of male sterility. The standard is based on a study of the alterations in the seminiferous tubes (T), the peritubular membranes (M) and the interstitial tissue (I). This method of histological assessment has been used to study 35 subjects on whom bilateral bipolar biopsies were carried out (130 specimens). The statistical study showed: a) the absence of any difference between the pieces taken from the two poles in each testis; b) the level of concentration of spermatozoa could not be tied up with any of the three histological parameters. This applied also for hormone levels with the exception of GUT which seem to correlate directly with M; c) the presence of a varicocoele does not reflect in any way the membrane or the interstitial tissue; d) spermograms carried out after the biopsies showed that testicular biopsy does not cause permanent trauma to the testis. The advantages and disadvantages of this quantitative method are discussed.
作者提出了一种在男性不育症调查框架内对睾丸活检组织病理学进行解读的标准。该标准基于对生精小管（T）、生精小管周围膜（M）和间质组织（I）变化的研究。这种组织学评估方法已用于研究35名接受双侧双极活检的受试者（130个标本）。统计研究表明：a）每个睾丸两极所取组织之间无任何差异；b）精子浓度水平与三个组织学参数中的任何一个均无关联。激素水平也是如此，除了似乎与M直接相关的促性腺激素释放激素（GUT）；c）精索静脉曲张的存在丝毫不会反映在膜或间质组织上；d）活检后进行的精液分析表明，睾丸活检不会对睾丸造成永久性损伤。本文讨论了这种定量方法的优缺点。
