Guttmann C R, Jolesz F A, Kikinis R, Killiany R J, Moss M B, Sandor T, Albert M S
Department of Radiology, Brigham & Women's Hospital, Boston, MA, USA.
Neurology. 1998 Apr;50(4):972-8. doi: 10.1212/wnl.50.4.972.
We evaluated brain tissue compartments in 72 healthy volunteers between the ages of 18 and 81 years with quantitative MRI. The intracranial fraction of white matter was significantly lower in the age categories above 59 years. The CSF fraction increased significantly with age, consistent with previous reports. The intracranial percentage of gray matter decreased somewhat with age, but there was no significant difference between the youngest subjects and the subjects above 59. A covariance adjustment for the volume of hyperintensities did not alter the foregoing results. The intracranial percentage of white matter volume was strongly correlated with the percentage volume of CSF. The finding of a highly significant decrease with age in white matter, in the absence of a substantial decrease in gray matter, is consistent with recent neuropathologic reports in humans and nonhuman primates.
我们使用定量磁共振成像（MRI）对72名年龄在18至81岁之间的健康志愿者的脑组织成分进行了评估。在59岁以上的年龄组中，白质的颅内占比显著降低。脑脊液（CSF）占比随年龄显著增加，这与先前的报道一致。灰质的颅内百分比随年龄略有下降，但最年轻的受试者与59岁以上的受试者之间没有显著差异。对高信号体积进行协方差调整并没有改变上述结果。白质体积的颅内百分比与脑脊液的体积百分比密切相关。在灰质没有大幅减少的情况下，白质随年龄显著减少这一发现与最近人类和非人类灵长类动物的神经病理学报告一致。
