Prior exposure to MK-801 sensitizes rats to ethanol-induced conditioned taste aversion.
作者信息
Bienkowski P, Koros E, Piasecki J, Kostowski W
机构信息
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
出版信息
Alcohol Alcohol. 1998 Mar-Apr;33(2):116-20. doi: 10.1093/oxfordjournals.alcalc.a008366.
Abstract
Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine [(+)MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.] significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05-.2 mg/kg) produced only a marginal CTA. Thus, pre-exposure to low, non-aversive doses of MK-801 may sensitize rats to the aversive stimulus effects of ethanol.
摘要
Zotero 插件