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在被动免疫小鼠中，用131I - 碘脱氧尿苷标记的细胞对L1210/MTX - R细胞进行体内抗体诱导杀伤，并对保留的放射性进行全身测量。

Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.

作者信息

Carlson G A, Terres G

出版信息

J Immunol. 1976 Sep;117(3):822-9.

PMID:956654
Abstract

The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant titer, independent of the complement system, and radioresistant. Although a large percentage of the leukemic cells was killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.

摘要

用131I - 碘脱氧尿苷标记的细胞和全身放射性保留测量法在体内跟踪了被动抗体对DBA/2J白血病L1210/MTX的LR亚系的杀伤作用。LR细胞在体内的杀伤与体外对2 - 巯基乙醇的抗性滴度成正比，与补体系统无关，且具有抗放射性。虽然在被动免疫的小鼠中有很大比例的白血病细胞被杀死，但被动抗血清的保护作用取决于宿主的主动免疫反应。

相似文献

1
Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.在被动免疫小鼠中，用131I - 碘脱氧尿苷标记的细胞对L1210/MTX - R细胞进行体内抗体诱导杀伤，并对保留的放射性进行全身测量。
J Immunol. 1976 Sep;117(3):822-9.
2
The effects of passive immunization with tumor-specific antiserum on the active immune response of mice to sublines of leukemia L1210.
J Immunol. 1978 Nov;121(5):1752-9.
3
Adoptive immunotherapy and chemo-immunotherapy in murine L-1210 leukemia and its influence on the kinetics of leukemic proliferation.过继性免疫疗法和化学免疫疗法对小鼠L-1210白血病的作用及其对白血病细胞增殖动力学的影响。
Arch Immunol Ther Exp (Warsz). 1979;27(6):819-27.
4
Correlations between humoral immunity and successful chemotherapy-immunotherapy.体液免疫与化疗-免疫疗法成功之间的相关性。
Cancer Res. 1976 Sep;36(9 pt.1):3051-7.
5
Monoclonal antibody-recognizing tumor-associated antigen of DBA/2 mouse lymphoma L1210 and its sublines.识别DBA/2小鼠淋巴瘤L1210及其亚系肿瘤相关抗原的单克隆抗体。
Transplant Proc. 1980 Sep;12(3):388-90.
6
Acceleration of allogeneic antitumor immunity with immune RNA in vitro and T-cell suppression by L1210 tumor bearer spleen cells.体外免疫核糖核酸加速同种异体抗肿瘤免疫及L1210荷瘤小鼠脾细胞对T细胞的抑制作用
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Selection for high immunogenicity in drug-resistant sublines of murine lymphomas demonstrated by plaque assay.通过噬斑测定法证明在小鼠淋巴瘤耐药亚系中选择高免疫原性。
Cancer Res. 1975 Apr;35(4):946-52.
8
Differential antigenic expression of the DBA/2 lymphoma L1210 and its sublines: cross-reactivity with C3H mammary tumors as defined by syngeneic monoclonal antibodies.DBA/2淋巴瘤L1210及其亚系的差异抗原表达：同基因单克隆抗体所定义的与C3H乳腺肿瘤的交叉反应性。
Cancer Res. 1983 Jun;43(6):2592-9.
9
Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro.L1210及其亚系的肿瘤免疫原性差异。I. 肿瘤细胞表面抗原密度增加对体外原发性B细胞反应的影响。
J Immunol. 1977 Sep;119(3):983-6.
10
Monoclonal antibodies to the L1210 murine leukemia cell line and to a drug-altered subline.针对L1210小鼠白血病细胞系及一种药物诱导的亚系的单克隆抗体。
Cancer Res. 1985 Nov;45(11 Pt 1):5299-303.

引用本文的文献

1
Allogeneic tumor rejection induced by the intravenous injection of Lyt-2+ cytolytic T lymphocyte clones.静脉注射Lyt-2+溶细胞性T淋巴细胞克隆诱导的同种异体肿瘤排斥反应。
J Exp Med. 1982 Oct 1;156(4):1280-5. doi: 10.1084/jem.156.4.1280.
2
Significance of cytotoxic lymphocytes after various immunizing procedures in a virus-induced non-producer syngeneic system: correlation between in vitro and in vivo lytic activity.病毒诱导的同基因非产生系统中各种免疫程序后细胞毒性淋巴细胞的意义：体外和体内裂解活性之间的相关性
Br J Cancer. 1980 Aug;42(2):275-83. doi: 10.1038/bjc.1980.227.
3
Lysis of uninfected and virus-infected cells in vivo: a rejection mechanism in addition to that mediated by natural killer cells.
体内未感染细胞和病毒感染细胞的溶解：一种除自然杀伤细胞介导之外的排斥机制。
J Virol. 1984 Jun;50(3):698-707. doi: 10.1128/JVI.50.3.698-707.1984.
4
Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.来自患有潜伏性红白血病小鼠的血清对体外培养的弗氏病毒红白血病细胞的抗原调制作用。
J Exp Med. 1977 Aug 1;146(2):520-34. doi: 10.1084/jem.146.2.520.
5
Pregnant mice are not primed but can be primed to fetal alloantigens.怀孕小鼠未被致敏，但可被胎儿同种异体抗原致敏。
Proc Natl Acad Sci U S A. 1979 May;76(5):2410-4. doi: 10.1073/pnas.76.5.2410.
6
Proceedings of the British Association For Cancer Research, 19th Annual General Meeting St. Edmund Hall, University of Oxford 4--6 April, 1978.英国癌症研究协会第19届年会会议记录，牛津大学圣埃德蒙学堂，1978年4月4日至6日
Br J Cancer. 1978 Jul;38(1):169-200. doi: 10.1038/bjc.1978.181.