Suppr超能文献

来自患有潜伏性红白血病小鼠的血清对体外培养的弗氏病毒红白血病细胞的抗原调制作用。

Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.

作者信息

Genovesi E V, Marx P A, Wheelock E F

出版信息

J Exp Med. 1977 Aug 1;146(2):520-34. doi: 10.1084/jem.146.2.520.

DOI:10.1084/jem.146.2.520
PMID:327016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180763/
Abstract

Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium containing normal mouse serum. After 48 h of culture in FLV-immune serum, 26% of the FLV erythroleukemic cells were devoid of FLV cell surface antigens as demonstrated by immunofluoresence. Antigenic modulation occurred to a greater extent in cells maintained in logarithmic growth than in cells in GO or resting phase. FLV-antigenic modulation is discussed as a possible mechanism by which antibody induces and maintains FLV-transformed cells in a dormant state.

摘要

在含有来自潜伏感染了Friend白血病病毒（FLV）的小鼠的FLV免疫血清的培养基中培养的FLV红白血病细胞，会发生FLV细胞表面抗原的调节。调节通过对FLV抗体介导的补体依赖性裂解的抗性增加来确定，并且在时间上与细胞表面FLV免疫复合物的帽化相关。当转移到含有正常小鼠血清的培养基中时，被调节的细胞恢复了对FLV抗体介导的补体依赖性裂解的敏感性。在FLV免疫血清中培养48小时后，通过免疫荧光证明，26%的FLV红白血病细胞缺乏FLV细胞表面抗原。与处于G0期或静止期的细胞相比，对数生长期的细胞中抗原调节的程度更大。FLV抗原调节被讨论为抗体诱导并维持FLV转化细胞处于休眠状态的一种可能机制。

相似文献

1
Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.来自患有潜伏性红白血病小鼠的血清对体外培养的弗氏病毒红白血病细胞的抗原调制作用。
J Exp Med. 1977 Aug 1;146(2):520-34. doi: 10.1084/jem.146.2.520.
2
Susceptibility of Friend virus antigen-modulated erythroleukemic cells to lysis by T lymphocytes from mice with dormant Friend virus infections.弗氏病毒抗原调节的红白血病细胞对来自潜伏性弗氏病毒感染小鼠的T淋巴细胞介导的裂解作用的敏感性。
J Immunol. 1979 Mar;122(3):795-800.
3
A radiosensitive T-lymphocyte associated with resistance of DBA/2 mice harboring Friend leukemia virus-dormant infections to transplantable Friend leukemia virus-erythroleukemia cells.一种放射敏感的T淋巴细胞，与携带Friend白血病病毒潜伏感染的DBA/2小鼠对可移植的Friend白血病病毒-红白血病细胞的抗性相关。
Cancer Res. 1986 Jan;46(1):127-32.
4
Effect of serum from mice with dormant Friend leukemia viral infections on synthesis and modulation of erythroleukemia cell surface gp70.来自患有潜伏性Friend白血病病毒感染的小鼠血清对红白血病细胞表面gp70合成及调节的影响
J Immunol. 1980 Aug;125(2):616-22.
5
Immunotherapy of murine leukemia. IX. The requirement for the Fc portion of antibody for successful passive serum therapy of Friend leukemia virus-induced disease.小鼠白血病的免疫疗法。IX. 对抗体Fc部分的需求，以实现对弗瑞德白血病病毒诱导疾病的成功被动血清疗法。
Virology. 1983 Apr 15;126(1):259-66. doi: 10.1016/0042-6822(83)90477-4.
6
In vitro growth inhibition of murine leukemia cells by antibody specific for the major envelope glycoprotein (gp71) of Friend leukemia virus.针对弗氏白血病病毒主要包膜糖蛋白（gp71）的抗体对小鼠白血病细胞的体外生长抑制作用。
J Cell Physiol. 1983 Nov;117(2):215-29. doi: 10.1002/jcp.1041170213.
7
Immunotherapy of murine leukemia. XI. differential susceptibility of spleen cells from serum-protected mice to the in vitro immunosuppressive effects of Friend leukemia virus-infected splenocytes.小鼠白血病的免疫疗法。十一、血清保护小鼠脾细胞对Friend白血病病毒感染的脾细胞体外免疫抑制作用的不同敏感性。
Int J Cancer. 1984 Aug 15;34(2):269-76. doi: 10.1002/ijc.2910340220.
8
The detection of a spleen focus-forming virus neoantigen by lymphocyte-mediated cytolysis.通过淋巴细胞介导的细胞溶解检测脾灶形成病毒新抗原。
J Exp Med. 1978 Jul 1;148(1):18-31. doi: 10.1084/jem.148.1.18.
9
Effects of in vivo Friend leukemia virus infection on levels of serum thymic factors and on selected T-cell functions in mice.体内Friend白血病病毒感染对小鼠血清胸腺因子水平及选定T细胞功能的影响。
Cancer Res. 1983 Sep;43(9):4355-63.
10
Immunoglobulins in human serum reactive with murine Friend leukaemia virus.人血清中与鼠源弗氏白血病病毒反应的免疫球蛋白。
J Gen Virol. 1980 Feb;46(2):311-24. doi: 10.1099/0022-1317-46-2-311.

引用本文的文献

1
Establishment and control of the L5178Y-cell tumor dormant state in DBA/2 mice.DBA/2小鼠中L5178Y细胞肿瘤休眠状态的建立与调控
Cancer Metastasis Rev. 1982;1(1):29-44. doi: 10.1007/BF00049479.
2
In vitro modulation of viral cell surface glycoproteins by anti-viral antibody in the presence of complement.在补体存在的情况下，抗病毒抗体对病毒细胞表面糖蛋白的体外调节作用。
Clin Exp Immunol. 1982 Dec;50(3):507-14.
3
Antibody-mediated destruction of virus-infected cells.抗体介导的病毒感染细胞的破坏。
Adv Immunol. 1980;29:209-60. doi: 10.1016/s0065-2776(08)60045-0.
4
Persistence and pathogenicity of defective Friend spleen focus-forming virus. Decreased transplantability of hemopoietic cells as a marker for preleukemic change.缺陷型弗氏脾集落形成病毒的持续性和致病性。造血细胞移植能力下降作为白血病前期变化的一个标志。
J Exp Med. 1979 Feb 1;149(2):340-57. doi: 10.1084/jem.149.2.340.
5
Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.抗体诱导的Friend病毒细胞表面抗原调节可降低持续性红白血病细胞的病毒产生：Rfv-3基因的影响。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5784-8. doi: 10.1073/pnas.76.11.5784.
6
Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.病毒诱导的红细胞白血病自然恢复后，感染性弗氏病毒在小鼠脾脏中的持续存在。
J Virol. 1979 Dec;32(3):832-7. doi: 10.1128/JVI.32.3.832-837.1979.
7
Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.抗Friend病毒抗体与白血病小鼠病毒血症的恢复及病毒白血病细胞表面抗原的丧失有关。鉴定Rfv-3为影响抗体产生的基因座。
J Exp Med. 1979 Jul 1;150(1):10-9. doi: 10.1084/jem.150.1.10.
8
Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice.在F1小鼠红白血病进展过程中，抗体诱导的Friend病毒白血病细胞表面抗原丢失发生。
J Exp Med. 1978 Nov 1;148(5):1109-21. doi: 10.1084/jem.148.5.1109.
9
Membrane-bound antibodies to bloodstream Trypanosoma cruzi in mice: strain differences in susceptibility to complement-mediated lysis.小鼠体内针对血液中克氏锥虫的膜结合抗体：对补体介导裂解的易感性存在品系差异。
Clin Exp Immunol. 1979 Sep;37(3):416-23.

本文引用的文献

1
DEMONSTRATION OF MOUSE ISOANTIGENS AT THE CELLULAR LEVEL BY THE FLUORESCENT ANTIBODY TECHNIQUE.用荧光抗体技术在细胞水平上显示鼠同种抗原。
J Exp Med. 1961 Sep 30;114(4):415-34. doi: 10.1084/jem.114.4.415.
2
QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS.使用铬-51标记靶细胞对小鼠H-2抗体进行定量滴定
Transplantation. 1965 May;3:423-31. doi: 10.1097/00007890-196505000-00011.
3
Erythrocytic maturation in vitro of murine (Friend) virus-induced leukemic cells.小鼠（弗瑞德）病毒诱导的白血病细胞在体外的红细胞成熟过程。
Natl Cancer Inst Monogr. 1966 Sep;22:505-22.
4
Mouse histocompatibility isoantigens derived from normal and from tumour cells.源自正常细胞和肿瘤细胞的小鼠组织相容性同种抗原。
Immunology. 1966 Aug;11(2):115-25.
5
Suppression of established Friend virus leukemia by statolon. I. Demonstration of a latent infection in clinically normal mice.静灰菌素对已建立的弗瑞德病毒白血病的抑制作用。I. 临床正常小鼠中潜伏感染的证明
J Virol. 1969 Jul;4(1):1-6. doi: 10.1128/JVI.4.1.1-6.1969.
6
Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro.抗原调制。暴露于TL抗体的细胞中TL抗原的丧失。该现象的体外研究。
J Exp Med. 1968 Mar 1;127(3):523-39. doi: 10.1084/jem.127.3.523.
7
Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody.胸腺白血病（TL）抗体对细胞膜抗原结构的修饰。
Proc Natl Acad Sci U S A. 1967 Sep;58(3):954-7. doi: 10.1073/pnas.58.3.954.
8
Suppression of established Friend virus leukemia by statolon. 3. Development of FV-leukemogenic and FV-immunogenic activities in bloods, spleens, and lymph nodes.静丝菌素对已建立的弗氏病毒白血病的抑制作用。3. 血液、脾脏和淋巴结中弗氏病毒致白血病活性和弗氏病毒免疫原性活性的发展。
J Natl Cancer Inst. 1971 Apr;46(4):797-802.
9
Suppression of established Friend virus leukemia by statolon. IV. Role of humoral antibody in the development of a dormant infection.制瘤素对已建立的Friend病毒白血病的抑制作用。IV. 体液抗体在潜伏感染发展中的作用。
J Natl Cancer Inst. 1972 Mar;48(3):665-73.
10
Suppression of Gross leukemia cell-surface antigens: a kind of antigenic modulation.白血病细胞总表面抗原的抑制：一种抗原调变。
J Natl Cancer Inst. 1972 Jul;49(1):183-92.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验