Joutsiniemi S L, Ilvonen T, Sinkkonen J, Huotilainen M, Tervaniemi M, Lehtokoski A, Rinne T, Näätänen R
Department of Psychology, University of Helsinki, Finland.
Electroencephalogr Clin Neurophysiol. 1998 Mar;108(2):154-9. doi: 10.1016/s0168-5597(97)00082-8.
The amplitude and latency of the mismatch negativity (MMN) elicited by occasional shorter-duration tones (25 and 50 ms) in a sequence of 75 ms standard tones were studied in 40 healthy subjects (9-84 years). The replicability and age dependence of the MMN-responses were determined. The 25 ms deviant tone evoked a clear response in 39 of the subjects, while the 50 ms deviant tone evoked an observable MMN only in 32 of the subjects. The MMN peak amplitude for the 25 ms deviants was significantly larger than for the 50 ms deviants. There was no significant difference in the peak latencies (measured from stimulus offset). For the 25 ms deviant, the amplitude diminished with increasing age. The MMN curves for the 25 ms deviant, measured on separate days in 14 subjects, looked very replicable. As a result of noise and filtering effect, the product-moment correlations were poor. The results indicate that the signal-to-noise ratio for the MMN to 25 ms deviants, obtained even in a 25 min recording session, is large enough for clinical use and individual diagnostics when undetectable (or very low amplitude) MMN is used as a sign of pathology. However, judged from the low correlation coefficients, despite the good replicability in visual evaluation, better methods for MMN quantification have to be used for clinical follow-up.
在40名健康受试者（9至84岁）中，研究了在75毫秒标准音调序列中偶尔出现的较短时长音调（25毫秒和50毫秒）所引发的失匹配负波（MMN）的波幅和潜伏期。确定了MMN反应的可重复性和年龄依赖性。25毫秒的偏差音调在39名受试者中引发了明显反应，而50毫秒的偏差音调仅在32名受试者中引发了可观察到的MMN。25毫秒偏差音调的MMN峰值波幅显著大于50毫秒偏差音调的。峰值潜伏期（从刺激偏移开始测量）没有显著差异。对于25毫秒的偏差音调，波幅随年龄增长而减小。在14名受试者的不同日期测量的25毫秒偏差音调的MMN曲线看起来非常具有可重复性。由于噪声和滤波效应，积差相关性较差。结果表明，即使在25分钟的记录过程中获得的MMN对25毫秒偏差音调的信噪比，对于临床应用和个体诊断来说足够大，当不可检测（或非常低波幅）的MMN被用作病理学标志时。然而，从低相关系数判断，尽管在视觉评估中具有良好的可重复性，但对于临床随访必须使用更好的MMN量化方法。
