Orcheson L J, Rickard S E, Seidl M M, Thompson L U
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
Cancer Lett. 1998 Mar 13;125(1-2):69-76. doi: 10.1016/s0304-3835(97)00482-5.
Flaxseed and its mammalian lignan precursor secoisolariciresinol diglycoside (SDG) have been shown to be mammary cancer-protective in rats. Thus, the antiestrogenic effects of flaxseed and SDG were compared with tamoxifen, an antiestrogen, by monitoring rat estrous cycling. Four-week supplementation of a high-fat diet with flaxseed (2.5, 5, or 10%) or SDG (0.75, 1.5 or 3.0 mg/day) produced a dose-related cessation or lengthening (by 18-39%) of estrous cycles in up to 66% of rats. With tamoxifen (1 mg/kg body weight/day), 83% of the animals had irregular cycles or were in persistent diestrus. Flaxseed and SDG were antiestrogenic without gross tissue toxicity.
亚麻籽及其哺乳动物木脂素前体开环异落叶松脂素二葡萄糖苷（SDG）已被证明对大鼠有预防乳腺癌的作用。因此，通过监测大鼠的发情周期，将亚麻籽和SDG的抗雌激素作用与抗雌激素药物他莫昔芬进行了比较。用亚麻籽（2.5%、5%或10%）或SDG（0.75毫克/天、1.5毫克/天或3.0毫克/天）对高脂饮食进行四周的补充，在高达66%的大鼠中产生了与剂量相关的发情周期停止或延长（延长18%-39%）。使用他莫昔芬（1毫克/千克体重/天）时，83%的动物出现周期不规律或持续处于间情期。亚麻籽和SDG具有抗雌激素作用，且无明显的组织毒性。
