Fernandez T, Saranath D, Advani S H, Deo M G, Soman C S
Cancer Genes Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai, India.
Cancer Lett. 1998 Mar 13;125(1-2):165-9. doi: 10.1016/s0304-3835(97)00509-0.
We examined 89 non-Hodgkin's lymphoma (NHL) patients of Indian origin for EcoRI restriction fragment length polymorphism (RFLP) of the L-myc gene with a view to testing the hypothesis that the presence of the L-myc S-allele predisposes towards NHL. We found no significant difference either in the distribution of the LL, LS and SS genotypes or in the allelic frequencies between the patient group and the control group with the frequencies of L-myc alleles, L (10.0 kb) and S (6.6 kb), being 0.56 and 0.44, respectively, in the patient group and 0.54 and 0.46, respectively, in the control group. However, a higher proportion (70%) of the S-allele was observed in our control group of normal healthy volunteers. Thus, the presence of L-myc S-allele did not indicate increased susceptibility or predisposition to the malignancy.
我们检测了89名印度裔非霍奇金淋巴瘤（NHL）患者的L-myc基因EcoRI限制性片段长度多态性（RFLP），以检验L-myc S等位基因的存在易患NHL这一假说。我们发现，患者组和对照组之间的LL、LS和SS基因型分布或等位基因频率均无显著差异，L-myc等位基因L（10.0 kb）和S（6.6 kb）的频率在患者组中分别为0.56和0.44，在对照组中分别为0.54和0.46。然而，在我们的正常健康志愿者对照组中观察到较高比例（70%）的S等位基因。因此，L-myc S等位基因的存在并不表明对恶性肿瘤的易感性增加或易患性。
