L-myc癌基因S等位基因在非霍奇金淋巴瘤中的频率增加。
Increased frequency of the S allele of the L-myc oncogene in non-Hodgkin's lymphoma.
作者信息
Crossen P E, Morrison M J, Colls B M
机构信息
Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
出版信息
Br J Cancer. 1994 Apr;69(4):759-61. doi: 10.1038/bjc.1994.143.
Abstract
We studied 100 patients with non-Hodgkin's lymphoma, 44 patients with Hodgkin's disease and 100 controls for the prevalence of the EcoRI restriction fragment polymorphism of the L-myc oncogene. No difference in the frequency of the three genotypes (LL, LS, SS) was found between the patient and control groups. However, the S allele was found to occur more frequently in the non-Hodgkin's lymphoma patients (chi 2 = 4.57, P = 0.032). These data confirm an earlier report and suggest that the presence of the S allele is associated with susceptibility to non-Hodgkin's lymphoma.
摘要
我们研究了100例非霍奇金淋巴瘤患者、44例霍奇金病患者以及100名对照者，以了解L-myc癌基因EcoRI限制性片段多态性的流行情况。患者组和对照组之间未发现三种基因型（LL、LS、SS）的频率存在差异。然而，发现S等位基因在非霍奇金淋巴瘤患者中出现的频率更高（卡方 = 4.57，P = 0.032）。这些数据证实了先前的一份报告，并表明S等位基因的存在与非霍奇金淋巴瘤的易感性有关。
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本文引用的文献
1
Alkaline transfer of DNA to plastic membrane.
Biochem Biophys Res Commun. 1984 Jul 18;122(1):340-4. doi: 10.1016/0006-291x(84)90480-7.
2
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
Anal Biochem. 1983 Jul 1;132(1):6-13. doi: 10.1016/0003-2697(83)90418-9.
3
A simple method for DNA purification from peripheral blood.
Anal Biochem. 1988 Nov 1;174(2):485-8. doi: 10.1016/0003-2697(88)90047-4.
4
Genetic predisposition to human lung cancer.
Br J Cancer. 1986 Apr;53(4):453-7. doi: 10.1038/bjc.1986.72.
5
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.
Nature. 1985;318(6041):69-73. doi: 10.1038/318069a0.
6
Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.
Proc Natl Acad Sci U S A. 1985 Oct;82(20):7068-70. doi: 10.1073/pnas.82.20.7068.
7
Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs.
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2353-6. doi: 10.1073/pnas.85.7.2353.
8
Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.
Nature. 1985;313(6001):369-74. doi: 10.1038/313369a0.
9
Restriction fragment length polymorphisms of L-myc and myb in human leukaemia and lymphoma in relation to age-selected controls.
Br J Cancer. 1989 Dec;60(6):872-4. doi: 10.1038/bjc.1989.382.
10
Restriction fragment length polymorphism of the L-myc gene and susceptibility to metastasis in renal cancer patients.
Int J Cancer. 1989 Mar 15;43(3):391-4. doi: 10.1002/ijc.2910430307.
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