维生素A对干扰素产生的抑制作用。
Suppression of interferon production by vitamin A.
作者信息
Blalock J E, Gifford G
出版信息
J Gen Virol. 1976 Jul;32(1):143-7. doi: 10.1099/0022-1317-32-1-143.
PMID:956786
Abstract
Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.
摘要
维生素A（视黄酸）抑制感染新城疫病毒（NDV）的L细胞产生干扰素。当细胞在新城疫病毒吸附后用视黄酸处理2小时时，这种抑制作用最大，这表明抑制步骤是一个早期事件。它不是由于总RNA合成的抑制。视黄酸处理导致干扰素出现延迟以及此后合成速率降低。
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