Mansour G, Charlotte F, Calvez V, Davi F, Merle-Béral H
Department of Pathology, Pitié-Salpêtrière Hospital, Paris, France.
Acta Cytol. 1998 Mar-Apr;42(2):371-3. doi: 10.1159/000331618.
Pleural effusions are common in patients with the acquired immunodeficiency syndrome (AIDS). Their most frequent causes are Kaposi's sarcoma and mycobacterial infections. We report cytologic, immunophenotypic and molecular features of a primary pleural non-Hodgkin's lymphoma (NHL) that represent an uncommon cause of isolated pleural effusion in patients with AIDS.
A 66-year-old, human immunodeficiency virus-positive male presented with chest pain and dyspnea. He had no history of opportunistic infections or Kaposi's sarcoma. A chest radiography displayed a right-sided pleural effusion. Cytology of pleural fluid revealed lymphomatous cells with markedly irregular nuclei. Their immunophenotype was indeterminate. Computed tomography of the thorax and abdomen did not show any tumor mass. Molecular analysis demonstrated that the lymphomatous cells had a B-cell genotype and contained Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) DNA sequences.
This case belongs to a new subgroup of AIDS-related NHL that is characterized by unusual morphology, null immunophenotype, B-cell genotype and association with both KSHV and EBV.
胸腔积液在获得性免疫缺陷综合征（AIDS）患者中很常见。其最常见的病因是卡波西肉瘤和分枝杆菌感染。我们报告了一例原发性胸膜非霍奇金淋巴瘤（NHL）的细胞学、免疫表型和分子特征，该淋巴瘤是AIDS患者孤立性胸腔积液的罕见病因。
一名66岁的男性，人类免疫缺陷病毒阳性，出现胸痛和呼吸困难。他没有机会性感染或卡波西肉瘤病史。胸部X线显示右侧胸腔积液。胸腔积液细胞学检查发现淋巴瘤细胞，核明显不规则。其免疫表型不确定。胸部和腹部计算机断层扫描未显示任何肿瘤肿块。分子分析表明，淋巴瘤细胞具有B细胞基因型，并且含有卡波西肉瘤相关疱疹病毒（KSHV）和EB病毒（EBV）的DNA序列。
该病例属于AIDS相关NHL的一个新亚组，其特征为形态异常、免疫表型阴性、B细胞基因型以及与KSHV和EBV均有关联。
