Ansari M Q, Dawson D B, Nador R, Rutherford C, Schneider N R, Latimer M J, Picker L, Knowles D M, McKenna R W
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072, USA.
Am J Clin Pathol. 1996 Feb;105(2):221-9. doi: 10.1093/ajcp/105.2.221.
Five patients with advanced AIDS developed a unique type of high grade primary body cavity-based non-Hodgkin's lymphoma (NHL). The lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. All of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. Immunophenotypically the lymphoma cells lacked expression of any B- or T-lymphocyte antigens, but expressed CD45 and the activation antigens CD30, CD38, CD71, and HLA-DR. Clonally rearranged immunoglobulin heavy chain and kappa light chain genes were identified by Southern blot analysis. Molecular studies also revealed Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) genomes and germline configuration of the c-myc protooncogene. In two cases studied cytogenetically, the lymphoma cells manifested complex chromosome abnormalities. These lymphomas are clinically and biologically unique and found predominantly in patients with advanced AIDS, in many cases with pre-existing Kaposi's sarcoma.
五名晚期艾滋病患者发生了一种独特类型的高级别原发性体腔型非霍奇金淋巴瘤（NHL）。这些淋巴瘤仅存在于浆液性积液中，体腔内未检测到肿块性病变，也无淋巴结病或器官肿大。所有淋巴瘤均表现出几乎相同的形态，无法精确分类，但似乎兼具大细胞免疫母细胞性淋巴瘤和间变性大细胞淋巴瘤的特征。免疫表型上，淋巴瘤细胞缺乏任何B或T淋巴细胞抗原的表达，但表达CD45以及活化抗原CD30、CD38、CD71和HLA-DR。通过Southern印迹分析鉴定出克隆性重排的免疫球蛋白重链和κ轻链基因。分子研究还揭示了爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV）基因组以及c-myc原癌基因的种系构型。在两例进行细胞遗传学研究的病例中，淋巴瘤细胞表现出复杂的染色体异常。这些淋巴瘤在临床和生物学上具有独特性，主要见于晚期艾滋病患者，在许多病例中伴有既往存在的卡波西肉瘤。
