Pearlman A L, Faust P L, Hatten M E, Brunstrom J E
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Curr Opin Neurobiol. 1998 Feb;8(1):45-54. doi: 10.1016/s0959-4388(98)80007-x.
Analysis of genetic mutations that lead to abnormal migration and layer formation in the developing cerebral cortex of mice and humans has led to important new discoveries regarding the molecular mechanisms that underlie these processes. Genetic manipulation and experimental analysis have demonstrated significant tangential migrations of cortical neurons, some arriving from very distant noncortical sites.
对导致小鼠和人类发育中的大脑皮质出现异常迁移和分层形成的基因突变进行分析，已带来有关这些过程潜在分子机制的重要新发现。基因操作和实验分析表明，皮质神经元存在显著的切向迁移，其中一些神经元来自非常遥远的非皮质部位。
