Ohtsuka T
Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan.
Dermatology. 1998;196(2):204-7. doi: 10.1159/000017899.
It remains unknown whether the life span of systemic sclerosis (SSc) skin fibroblasts (FB) and that of normals are the same or not, though SSc skin FB have been shown to present abnormalities such as elevated collagen synthesis.
To find out whether the life span of SSc skin FB and that of normals are the same or not.
Cell generation and colony-forming efficiency were calculated in 10 normal and 7 SSc FB, and total life spans were studied.
Colony-forming efficiency decreased from 30 to 5% until the cells reached senescence. The cell generations of normal and SSc FB showed no significant difference.
SSc FB is senescent and may indicate that the senescence of SSc FB is independent of its abnormal features.
尽管系统性硬化症（SSc）皮肤成纤维细胞（FB）已被证明存在诸如胶原蛋白合成增加等异常情况，但其寿命与正常人皮肤成纤维细胞是否相同仍不清楚。
探究SSc皮肤FB的寿命与正常人的是否相同。
计算10例正常皮肤FB和7例SSc皮肤FB的细胞传代和集落形成效率，并研究其总寿命。
在细胞达到衰老之前，集落形成效率从30%降至5%。正常皮肤FB和SSc皮肤FB的细胞传代没有显著差异。
SSc皮肤FB发生衰老，这可能表明SSc皮肤FB的衰老与其异常特征无关。
