Rallidis L S, Papageorgakis N H, Megalou A A, Exadactylos N J, Tsitouris G K, Papasteriadis E G
Department of Cardiology, General Hospital of Nikea, Piraeus, Greece.
Eur Heart J. 1998 Mar;19(3):395-401. doi: 10.1053/euhj.1997.0770.
The present study aimed to assess the incidence and type of lipid disorders in the offspring of young Greek coronary patients.
One hundred and ninety-three children and youngsters were divided into two groups. Group A consisted of 104 children whose fathers had sustained a myocardial infarction before the age of 55 years. Eighty-nine young subjects matched for age, gender, dietary and smoking habits without a familial history of coronary artery disease served as controls (group B). Total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and lipoprotein(a) were measured in the children and the affected fathers.
Fifty-three percent of the offspring of young coronary patients had elevated total cholesterol or elevated triglycerides or decreased high density lipoprotein cholesterol or a combination, while the 80.4% of the affected fathers had lipid disorders. The distribution of lipid disorders in the children bore a striking resemblance to those seen in their affected fathers and there was a significant correlation between offspring-father total cholesterol, low density lipoprotein cholesterol and lipoprotein(a). When excess lipoprotein(a) was added to the lipid disorders the incidence of dyslipidaemia in the offspring of the affected individuals was increased to 63.5%.
Dyslipidaemia is very common in the offspring of Greek men with premature coronary artery disease; this occurrence emphasizes the need always to evaluate the lipid profile in these children. The detection of dyslipidaemia necessitates the early institution of preventive measures with the expectation that the incidence of cardiovascular disease will decrease later in life.
本研究旨在评估希腊年轻冠心病患者后代中脂质紊乱的发生率及类型。
193名儿童和青少年被分为两组。A组由104名儿童组成，他们的父亲在55岁之前发生过心肌梗死。89名年龄、性别、饮食习惯和吸烟习惯相匹配且无冠心病家族史的年轻受试者作为对照组（B组）。对这些儿童及其患病父亲测量了总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和脂蛋白(a)。
年轻冠心病患者的后代中，53%患有总胆固醇升高或甘油三酯升高或高密度脂蛋白胆固醇降低或多种情况并存，而患病父亲中80.4%有脂质紊乱。儿童中脂质紊乱的分布与他们患病父亲的情况极为相似，后代与父亲的总胆固醇、低密度脂蛋白胆固醇和脂蛋白(a)之间存在显著相关性。当将脂蛋白(a)升高纳入脂质紊乱情况时，患病个体后代中血脂异常的发生率增至63.5%。
血脂异常在希腊患有早发性冠心病男性的后代中非常常见；这种情况强调了始终对这些儿童进行血脂谱评估的必要性。血脂异常的检测需要尽早采取预防措施，以期降低日后心血管疾病的发生率。
