Rallidis L S, Papageorgakis N H, Megalou A A, Anagnostou E D, Chatzidimitriou G I, Tsitouris G K
Department of Cardiology, Evangelismos Hospital, Greece.
Eur Heart J. 1995 Dec;16(12):1814-8. doi: 10.1093/oxfordjournals.eurheartj.a060833.
We examined whether the levels of fibrinogen are elevated in the offspring of middle-aged coronary patients. One hundred and seventy-six young subjects were divided into two groups. Group A consisted of 100 children and youngsters (mean age 17 +/- 6 years) whose fathers had sustained a myocardial infarction under the age 55 years without associated history of diabetes mellitus or hypertension. Seventy-six healthy young subjects (mean age 18 +/- 5 years) matched for gender, dietary and smoking habits without familial history of coronary artery disease, diabetes mellitus or hypertension served as the control group (group B). Fibrinogen, total cholesterol, triglycerides, high and low density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B and lipoprotein (a) were measured. Sons and daughters with a history of premature paternal myocardial infarction had higher levels of fibrinogen compared with control subjects (304.1 +/- 60 vs 274 +/- 53 mg. dl-1, P < 0.001). This difference was maintained when the above groups were divided into single sex groups. Total cholesterol, low density lipoprotein cholesterol, apolipoprotein B and lipoprotein (a) were also significantly higher in group A. Children of affected individuals who had a good lipid profile also had significantly higher fibrinogen levels compared to control group. The results support the hypothesis that the higher plasma levels of fibrinogen in the offspring of middle-aged coronary men could partially explain their predisposition for coronary artery disease. Since the levels of fibrinogen have a major genetic component, they could be a useful marker in identifying children at high risk for coronary artery disease, especially among those with no lipid abnormalities.
我们研究了中年冠心病患者的后代纤维蛋白原水平是否升高。176名年轻受试者被分为两组。A组由100名儿童和青少年（平均年龄17±6岁）组成，他们的父亲在55岁以下发生过心肌梗死，且无糖尿病或高血压相关病史。76名健康年轻受试者（平均年龄18±5岁），性别、饮食和吸烟习惯相匹配，无冠心病、糖尿病或高血压家族史，作为对照组（B组）。检测了纤维蛋白原、总胆固醇、甘油三酯、高密度和低密度脂蛋白胆固醇、载脂蛋白A-1、载脂蛋白B和脂蛋白(a)。有父亲过早发生心肌梗死病史的子女，其纤维蛋白原水平高于对照组（304.1±60 vs 274±53 mg·dl-1，P<0.001）。当上述两组再分为单性别组时，这种差异仍然存在。A组的总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B和脂蛋白(a)也显著更高。脂质谱良好的患病个体的子女，其纤维蛋白原水平也显著高于对照组。结果支持这样的假设，即中年冠心病男性后代中较高的血浆纤维蛋白原水平可能部分解释了他们患冠状动脉疾病的易感性。由于纤维蛋白原水平有很大的遗传成分，它们可能是识别冠状动脉疾病高危儿童的有用标志物，尤其是在那些无脂质异常的儿童中。
