Graadt van Roggen J F, Baatenberg-de Jong R J, Verschuur H P, Balhuizen J C, Slootweg P J, van Krieken J H
Department of Pathology, Leiden University Medical Centre, The Netherlands.
Histopathology. 1998 Mar;32(3):239-41. doi: 10.1046/j.1365-2559.1998.00382.x.
We document for the first time the occurrence of a malignant myoepithelioma at a site other than within the major and minor salivary glands.
A 67-year-old male presented with progressive symptoms and signs of a space-occupying lesion in the right maxillary sinus. An initial biopsy identified a malignant (myo)epithelial lesion and a radical maxillectomy was performed. Histology, supplemented by immunohistochemistry, confirmed the presence of a malignant myoepithelioma.
Malignant myoepithelioma is a very rare tumour composed almost exclusively of myoepithelial cells and, to date, has only been described arising in the the major and minor salivary glands. A variety of tumours of salivary tissue have been reported within the head and neck area at sites outside the major and minor salivary glands, probably arising within accessory salivary tissue. We report the first case of a malignant myoepithelioma occurring in the maxillary sinus, also presumably arising in accessory salivary tissue in this location.
我们首次记录了在大、小唾液腺以外的部位发生恶性肌上皮瘤的情况。
一名67岁男性患者出现右侧上颌窦占位性病变的进行性症状和体征。初步活检发现一个恶性（肌）上皮性病变，随后进行了根治性上颌骨切除术。组织学检查并辅以免疫组织化学检查，证实存在恶性肌上皮瘤。
恶性肌上皮瘤是一种非常罕见的肿瘤，几乎完全由肌上皮细胞组成，迄今为止，仅报道其发生于大、小唾液腺。头颈部区域大、小唾液腺以外的部位已报道有多种唾液腺组织肿瘤，可能起源于副唾液腺组织。我们报告了首例发生在上颌窦的恶性肌上皮瘤，推测也起源于该部位的副唾液腺组织。
