Umansky R, Watson J S
Child Development Center, Children's Hospital Oakland, CA 94609, USA.
J Child Neurol. 1998 Apr;13(4):158-62. doi: 10.1177/088307389801300402.
The influence of eye movements on hand use and pervasive stereotypies in Rett syndrome was studied, to better understand the developmental abnormality in this disorder. Nine patients in the post-regression phase were offered objects. As expected, the girls looked at the objects but usually did not reach for them. Nor were their characteristic hand stereotypies altered by such looking. But the occurrence of stereotypies was promoted by overall shifts in gaze, ie, eye movements in any direction. This finding may be relevant to the late-infancy loss of voluntary hand use in Rett syndrome associated with onset of pervasive stereotypies. It suggests a stage-specific regression to a level characteristic of normal 3-month-old infants who do not reach and grasp, but whose hand clasping and mouthing may be triggered by the perceptual consequences of exploratory eye movements and shifts in gaze.
为了更好地理解雷特综合征的发育异常，研究了眼动对手部使用和普遍刻板动作的影响。给9名处于回归后期的患者提供物品。不出所料，女孩们看着物品，但通常不会伸手去拿。她们特有的手部刻板动作也不会因这种注视而改变。但是，凝视的整体移动，即任何方向的眼动，会促使刻板动作的出现。这一发现可能与雷特综合征中与普遍刻板动作发作相关的婴儿后期自愿手部使用丧失有关。它表明存在一个特定阶段的倒退，退回到正常3个月大婴儿的水平，这些婴儿不会伸手抓握，但他们的手部紧握和口部动作可能由探索性眼动和凝视移动的感知结果触发。
