Baldwin T J
Institute of Infections and Immunity, School of Clinical Laboratory Sciences, University Hospital, Queen's Medical Centre, Nottingham.
J Med Microbiol. 1998 Apr;47(4):283-93. doi: 10.1099/00222615-47-4-283.
Enteropathogenic Escherichia coli (EPEC) remain an important world-wide cause of diarrhoeal disease and mortality of infants and young children. Research programmes around the world have, in recent times, made enormous strides towards a better understanding of EPEC pathogenesis, yielding unique insights into the molecular intercourse between host and pathogen. Recombinant DNA and cell biology techniques have provided powerful tools, giving the first intriguing glimpses of a wealth of bacterial products mediating complex host:pathogen interactions involving the subversion of normal host signalling processes. Much has been discovered since 1945, when E. coli was first implicated as a cause of diarrhoea. However, many questions remain unanswered and many more remain unasked. Much remains to be discovered, especially in the area of molecular interactions between host and pathogen and how they relate to the manifestation of disease in the patient.
肠致病性大肠杆菌（EPEC）仍然是全球婴幼儿腹泻疾病和死亡的重要原因。近年来，世界各地的研究项目在更好地理解EPEC发病机制方面取得了巨大进展，对宿主与病原体之间的分子相互作用有了独特的见解。重组DNA和细胞生物学技术提供了强大的工具，首次让人饶有兴趣地瞥见了大量介导复杂宿主：病原体相互作用的细菌产物，这些相互作用涉及颠覆正常的宿主信号传导过程。自1945年大肠杆菌首次被认为是腹泻病因以来，已经发现了很多东西。然而，许多问题仍未得到解答，还有更多问题尚未被提出。仍有许多有待发现的东西，特别是在宿主与病原体之间的分子相互作用领域，以及它们与患者疾病表现的关系方面。
