Portela A, Cornélissen G, Halberg F, Halberg F, Halberg J, Hofman M A, Swaab D F, Ikonomou O C, Stoynev A G
Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Spain.
In Vivo. 1995 Jul-Aug;9(4):347-58.
We here test for and detect anticipated about-yearly (circannual) changes in the volume and number of vasopressin-containing neurons in the human suprachiasmatic nucleus. We then resolve inferential statistical parameters quantifying the extent and timing (the amplitude and acrophase) of the circannual rhythm previously missed by data inspection and classical biometry. We parametrize about-half-yearly changes previously validated by non-parametric statistical tests. New dynamic circannual and circasemiannual endpoints thus become available for basic investigation and the assessment of disease risk elevation and/or chronoprotopathology. It was earlier demonstrated that the circannual rhythms of prolactin and TSH are prominent classifiers of individuals at high versus low familial and other risk for developing breast or prostate cancer. Any neurocrine or neural mechanisms contributing to this classification are now amenable to study, on a population basis, with the dynamic hypothalamic rhythm characteristics yielded by this metachronanalysis.
我们在此检测并发现人类视交叉上核中含血管加压素神经元的数量和体积预期的约每年一次（周年节律）的变化。然后，我们解析了推理统计参数，这些参数量化了此前通过数据检查和经典生物统计学未能发现的周年节律的程度和时间（振幅和高峰期）。我们对先前通过非参数统计检验验证的约半年一次的变化进行参数化。因此，新的动态周年和半年节律终点可用于基础研究以及疾病风险升高和/或时间原病理学的评估。早期研究表明，催乳素和促甲状腺激素的周年节律是患乳腺癌或前列腺癌的高家族风险和其他风险个体与低风险个体的重要分类指标。现在，基于人群，利用这种元时间分析产生的动态下丘脑节律特征，任何促成这种分类的神经内分泌或神经机制都适合进行研究。
