转移性类癌肿瘤的冷冻疗法。

Cryotherapy of metastatic carcinoid tumors.

作者信息

Shapiro R S, Shafir M, Sung M, Warner R, Glajchen N

机构信息

Department of Radiology, Mount Sinai School of Medicine of the City University of New York, NY 10029-6574, USA.

出版信息

Abdom Imaging. 1998 May-Jun;23(3):314-7. doi: 10.1007/s002619900348.

DOI:10.1007/s002619900348

PMID:9569305

Abstract

BACKGROUND

To describe the use of hepatic cryotherapy to treat patients with symptomatic carcinoid metastates.

METHODS

Hepatic cryotherapy was performed on five patients with carcinoid syndrome resulting from metastatic carcinoid tumors. Intraoperative ultrasound was used to guide the cryotherapy and to assess the adequacy of freezing.

RESULTS

All five patients had relief of the carcinoid syndrome after treatment. In four of the five patients, the relief was prolonged (>3 months); in one patient, the relief of symptoms was transient (2 months). Four of five patients had a transient reduction in hormonal tumor markers (the fifth patient did not have hormonal-level follow-up). During a follow-up period of 2.5 years, four of the five patients died. The 6-month survival rate was 80%, the 1-year survival rate was 60%, the 2-year survival rate was 40%, and the 2.5-year survival was 20%. One patient is alive 30 months after treatment.

CONCLUSION

Hepatic cryotherapy can provide symptomatic relief for patients with hepatic metastates producing the carcinoid syndrome.

摘要

背景

描述肝冷冻疗法治疗有症状的类癌转移患者的应用情况。

方法

对5例因转移性类癌肿瘤导致类癌综合征的患者实施肝冷冻疗法。术中超声用于引导冷冻疗法并评估冷冻是否充分。

结果

所有5例患者治疗后类癌综合征均得到缓解。5例患者中有4例缓解期延长（>3个月）；1例患者症状缓解是短暂的（2个月）。5例患者中有4例激素肿瘤标志物短暂下降（第5例患者未进行激素水平随访）。在2.5年的随访期内，5例患者中有4例死亡。6个月生存率为80%，1年生存率为60%，2年生存率为40%，2.5年生存率为20%。1例患者治疗后30个月仍存活。