Nieminen T, Eskola J, Käyhty H
National Public Health Institute, Helsinki, Finland.
Vaccine. 1998 Apr;16(6):630-6. doi: 10.1016/s0264-410x(97)00235-1.
The results from our previous study showed IgA dominated ASC responses to pneumococcal polysaccharide vaccine and to pneumococcal polysaccharide meningococcal outer membrane protein conjugate vaccine (PncOMPC) in adult volunteers. The results indicated that a high IgA ASC response is a useful indicator of a secretory IgA response in saliva. We believe that the mucosal immune responses is potentially an important characteristic of the pneumococcal vaccines and should thus be measured when the new pneumococcal conjugate vaccines are evaluated. In the present study, we studied two new tetravalent pneumococcal conjugate vaccines: the diphtheria toxoid and tetanus toxoid conjugates. In contrast to PncOMPC, these conjugates induced higher responses than the polysaccharide vaccine. Furthermore, the different structure of the two conjugate vaccines might affect the nature of the response. Thus a different vaccine may be optimal for induction of a mucosal response than is of systemic responses.
我们之前的研究结果表明，在成年志愿者中，IgA在对肺炎球菌多糖疫苗和肺炎球菌多糖-脑膜炎球菌外膜蛋白结合疫苗（PncOMPC）的ASC反应中占主导地位。结果表明，高IgA ASC反应是唾液中分泌型IgA反应的一个有用指标。我们认为，黏膜免疫反应可能是肺炎球菌疫苗的一个重要特征，因此在评估新型肺炎球菌结合疫苗时应予以测量。在本研究中，我们研究了两种新型四价肺炎球菌结合疫苗：白喉类毒素和破伤风类毒素结合物。与PncOMPC不同，这些结合物诱导的反应高于多糖疫苗。此外，两种结合疫苗的不同结构可能会影响反应的性质。因此，与诱导全身反应相比，不同的疫苗可能对诱导黏膜反应最为适宜。
