Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
GSF-Institut für Toxikologie, Oberschleissheim, Germany.
Chemosphere. 1998 Jan;36(2):271-95. doi: 10.1016/s0045-6535(97)00365-2.
SARs may enable the evaluation of the toxic potential of chemicals by drawing conclusions from available data on structurally-related chemicals, thus reducing the need for further testing. The Advisory Committee on Existing Chemicals of Environmental Relevance (BUA) [1,2] of the German Chemical Society (Gesellschaft Deutscher Chemiker [GDCh]) has compiled data on the toxicity and ecological impact for several groups of chemicals [3, 4]. In the present review, some common toxicological properties for aliphatic amines were revealed after evaluation and comparison of the toxicity data.
构效关系（SARs）可以通过从结构相关化学品的现有数据中得出结论，来评估化学品的潜在毒性，从而减少进一步测试的需求。德国化学学会（Gesellschaft Deutscher Chemiker [GDCh]）的环境相关现有化学品咨询委员会（BUA）[1,2] 已汇编了几组化学品的毒性和生态影响数据 [3, 4]。在本综述中，通过对毒性数据的评估和比较，揭示了脂肪族胺的一些常见毒理学特性。
