Umemura S, Yumita N, Okano Y, Kaneuchi M, Magario N, Ishizaki M, Shimizu K, Sano Y, Umemura K, Nishigaki R
Central Research Laboratory, Hitachi, Ltd., Kokubunnji, Tokyo, Japan.
Cancer Lett. 1997 Dec 23;121(2):195-201. doi: 10.1016/s0304-3835(97)00354-6.
Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 microM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.
