Umemura K, Yumita N, Nishigaki R, Umemura S
School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Cancer Lett. 1996 Apr 19;102(1-2):151-7. doi: 10.1016/0304-3835(96)04174-2.
The sonodynamically induced antitumor effect of pheophorbide a (Ph-a) was investigated. Both in vitro and in vivo effects on sarcoma 180 were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced cell damage in air-saturated suspension was enhanced by twice with 80 microM Ph-a. This enhancement was significantly inhibited by histidine, which may suggest it was mediated by ultrasonically induced oxidation. For mice, 5 mg/kg Ph-a was administered before the insonation, and ultrasound stopped the tumor growth at an intensity with which ultrasound alone showed only a slight antitumor effect.
研究了脱镁叶绿酸a（Ph-a）的声动力诱导抗肿瘤作用。在体外和体内，均结合2MHz的超声波测试了对肉瘤180的作用。在空气饱和悬浮液中，80μM的Ph-a使超声诱导的细胞损伤率提高了两倍。组氨酸可显著抑制这种增强作用，这可能表明其是由超声诱导的氧化介导的。对于小鼠，在超声照射前给予5mg/kg的Ph-a，在单独超声仅显示轻微抗肿瘤作用的强度下，超声抑制了肿瘤生长。
