Gold M, Hauser R A, Chen M F
University of South Florida College of Medicine, Department of Neurology, Tampa 33612, USA.
Metab Brain Dis. 1998 Mar;13(1):43-53. doi: 10.1023/a:1020678912330.
In this study we compared plasma and erythrocyte thiamine levels in a group of patients with idiopathic Parkinson's Disease (iPD) to a group of patients with probable Alzheimer's Disease (pAD). pAD patients had significantly lower plasma thiamine levels (raw and z-score) than iPD patients. A significantly higher number of pAD patients had plasma thiamine deficiencies than iPD patients. The demographics of our patient groups were similar to those reported by other investigators, making age, sex and nutritional status unlikely explanations for our findings. These results suggest that plasma thiamine deficiency is associated with pAD but not with iPD.
在本研究中，我们将一组特发性帕金森病（iPD）患者的血浆和红细胞硫胺素水平与一组可能患有阿尔茨海默病（pAD）的患者进行了比较。pAD患者的血浆硫胺素水平（原始值和z分数）显著低于iPD患者。pAD患者中血浆硫胺素缺乏的人数明显多于iPD患者。我们患者组的人口统计学特征与其他研究者报告的相似，这使得年龄、性别和营养状况不太可能解释我们的研究结果。这些结果表明，血浆硫胺素缺乏与pAD有关，而与iPD无关。
