Grosfeld J L, Ranochak J E
J Pediatr Surg. 1976 Jun;11(3):419-24. doi: 10.1016/s0022-3468(76)80198-4.
Following splenectomy, infant rats are at risk when challenged with pneumococcus. Mortality was 85% in splenectomized rats and 6.6% in controls. Rats subjected to a standardized splenic trauma had a 16% mortality when left untreated and a zero mortality with operative therapy by splenectomy, hemisplenectomy, or primary splenic repair. Hemisplenectomy and primary splenic repair are indeed feasible in rats with resultant splenic tissue showing a normal histologic appearance. Hemisplenectomized infant rats, when subjected to pneumococcal challenge, had a 15% mortality compared to 85% for splenectomized infant rats. This suggests that the repaired spleen retains its very important immunologic abiltiy to resist infection. Despite differences in species and organ sizes and shapes, these data suggest that partial splenectomy and primary splenic repair may be attractive alternatives to splenectomy in instances of trauma and inadvertant operative injury.
脾切除术后，幼鼠受到肺炎球菌攻击时会面临风险。脾切除的大鼠死亡率为85%，而对照组为6.6%。遭受标准化脾脏创伤的大鼠，未经治疗时死亡率为16%，而通过脾切除术、半脾切除术或脾脏原位修复术进行手术治疗时死亡率为零。半脾切除术和脾脏原位修复术在大鼠中确实可行，术后脾脏组织的组织学外观正常。接受肺炎球菌攻击时，半脾切除的幼鼠死亡率为15%，而脾切除的幼鼠死亡率为85%。这表明修复后的脾脏保留了其抵抗感染的非常重要的免疫能力。尽管物种以及器官大小和形状存在差异，但这些数据表明，在创伤和意外手术损伤的情况下，部分脾切除术和脾脏原位修复术可能是脾切除术有吸引力的替代方案。
