Touloukian R J, Dang C V, Caride V J
J Pediatr Surg. 1978 Apr;13(2):131-5. doi: 10.1016/s0022-3468(78)80005-0.
An experimental splenic dearterilization injury was created in 1-wk-old rats to study the effect of vascular trauma on splenic function. Splenic weight significantly decreased 1 wk following injury but returned to control values within a month. Total splenic nuclear activity diminished initially but increased to above control values 1 mo after injury, and finally returned to normal at 2 mo. Survival rate after an intraperitoneal challenge with pneumococcus in groups 1 wk following total splenectomy and partial dearterlization was not significantly different than controls. This study confirmed the clinical impression that vascular injury to the spleen causes only a transient impariment of splenic size and function and provides further incentive to perform splenorrhaphy following splenic trauma.
为研究血管损伤对脾脏功能的影响，在1周龄大鼠身上制造了实验性脾去动脉化损伤。损伤后1周脾脏重量显著下降，但在1个月内恢复到对照值。脾脏总核活性最初降低，但在损伤后1个月增加到高于对照值，最终在2个月时恢复正常。全脾切除和部分去动脉化后1周的组，腹腔注射肺炎球菌后的存活率与对照组无显著差异。本研究证实了临床印象，即脾脏血管损伤仅导致脾脏大小和功能的短暂损害，并为脾外伤后进行脾修补术提供了进一步的动力。
