Laudenslager M L, Aasal R, Adler L, Berger C L, Montgomery P T, Sandberg E, Wahlberg L J, Wilkins R T, Zweig L, Reite M L
University of Colorado Health Sciences Center, Department of Psychiatry, Denver 80220, USA.
Brain Behav Immun. 1998 Mar;12(1):74-9. doi: 10.1006/brbi.1997.0513.
Resting immune [WBC and differential cell counts lymphocyte phenotyping (CD2, CD4, CD8, CD16, CD20, and CD56), and NK activity] and endocrine (cortisol, prolactin, growth hormone, and DHEA-SO4) parameters were measured in 10 male, Vietnam combat veterans diagnosed with long-term post-traumatic stress disorder (PTSD) and 9 control Vietnam combat veterans without a PTSD diagnosis but with a comparable history of alcohol abuse. Subjects completed a battery of psychological questionnaires. We report on preliminary observations of the relationship between PTSD and physiological and psychological parameters. With some important exceptions, PTSD patients did not differ from the age-matched control group with regard to hormone levels or lymphocyte phenotypes. However, NK activity was higher in the PTSD population than in the controls. Beck, Mississippi, and Combat Exposure scores were significantly elevated in the PTSD population. In contrast to previous observations in depressed populations, depression (indicated by elevated Beck scores), comorbid with PTSD, was associated with increased natural cytotoxicity.
对10名被诊断患有长期创伤后应激障碍（PTSD）的男性越南退伍军人和9名未被诊断患有PTSD但有类似酗酒史的对照越南退伍军人，测量了静息免疫参数（白细胞计数及分类计数、淋巴细胞表型分析（CD2、CD4、CD8、CD16、CD20和CD56）以及自然杀伤细胞活性）和内分泌参数（皮质醇、催乳素、生长激素和硫酸脱氢表雄酮）。受试者完成了一系列心理问卷。我们报告了关于PTSD与生理和心理参数之间关系的初步观察结果。除了一些重要的例外情况，PTSD患者在激素水平或淋巴细胞表型方面与年龄匹配的对照组没有差异。然而，PTSD人群的自然杀伤细胞活性高于对照组。PTSD人群的贝克、密西西比和战斗暴露得分显著升高。与之前在抑郁症人群中的观察结果相反，与PTSD共病的抑郁症（以贝克得分升高表示）与自然细胞毒性增加有关。
