人类免疫缺陷病毒进入宿主细胞所需的肌动蛋白依赖性受体共定位。
Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells.
作者信息
Iyengar S, Hildreth J E, Schwartz D H
机构信息
Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA.
出版信息
J Virol. 1998 Jun;72(6):5251-5. doi: 10.1128/JVI.72.6.5251-5255.1998.
Abstract
Human immunodeficiency virus (HIV) envelope binds CD4 and a chemokine receptor in sequence, releasing hydrophobic viral gp41 residues into the target membrane. HIV entry required actin-dependent concentration of coreceptors, which could be disrupted by cytochalasin D (CytoD) without an effect on cell viability or mitosis. Pretreatment of peripheral blood mononuclear cells, but not virus, inhibited entry and infection. Immunofluorescent confocal microscopy of activated cells revealed CD4 and CXCR4 in nonoverlapping patterns. Addition of gp120 caused polarized cocapping of both molecules with subsequent pseudopod formation, while CytoD pretreatment blocked these membrane changes completely.
摘要
人类免疫缺陷病毒（HIV）包膜依次结合CD4和趋化因子受体，将疏水性病毒糖蛋白41（gp41）残基释放到靶细胞膜中。HIV进入需要肌动蛋白依赖性的共受体聚集，细胞松弛素D（CytoD）可破坏这种聚集，且对细胞活力或有丝分裂无影响。对外周血单核细胞而非病毒进行预处理可抑制病毒进入和感染。对活化细胞进行免疫荧光共聚焦显微镜检查显示，CD4和CXCR4呈非重叠模式。添加gp120会导致这两种分子发生极化共帽化，随后形成伪足，而CytoD预处理则完全阻断了这些膜变化。
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本文引用的文献
1
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor.嗜巨噬细胞性HIV和SIV包膜蛋白通过CCR5趋化因子受体诱导信号。
Nature. 1997 Oct 30;389(6654):981-5. doi: 10.1038/40173.
2
Requirements for different components of the host cell cytoskeleton distinguish ecotropic murine leukemia virus entry via endocytosis from entry via surface fusion.宿主细胞细胞骨架不同组分的需求区分了嗜亲性鼠白血病病毒通过内吞作用的进入方式与通过表面融合的进入方式。
J Virol. 1997 Oct;71(10):7145-56. doi: 10.1128/JVI.71.10.7145-7156.1997.
3
HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.人类免疫缺陷病毒1型糖蛋白120（HIV-1 gp120）诱导CD4与趋化因子受体CXCR4之间产生关联。
J Immunol. 1997 Sep 15;159(6):3000-8.
4
Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.鉴定人巨细胞病毒编码的一种趋化因子受体作为HIV-1进入的辅助因子。
Science. 1997 Jun 20;276(5320):1874-8. doi: 10.1126/science.276.5320.1874.
5
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.通过与不同的CCR5和CXCR4结构域相互作用，HIV-1共受体使用情况的演变
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6426-31. doi: 10.1073/pnas.94.12.6426.
6
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.半胱天冬酶介导的PAK2激活调控凋亡细胞中的膜及形态变化。
Science. 1997 Jun 6;276(5318):1571-4. doi: 10.1126/science.276.5318.1571.
7
STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.STRL33，一种新型趋化因子受体样蛋白，作为巨噬细胞嗜性和T细胞系嗜性HIV-1的融合辅助因子发挥作用。
J Exp Med. 1997 Jun 2;185(11):2015-23. doi: 10.1084/jem.185.11.2015.
8
The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.在体外和体内的程序性细胞死亡过程中，以及在HIV-1感染中，脱落膜颗粒的意义。
J Clin Invest. 1997 Apr 1;99(7):1546-54. doi: 10.1172/JCI119317.
9
Highly purified CD25- resting T cells cannot be infected de novo with HIV-1.高度纯化的静止型CD25⁺ T细胞不能被HIV-1重新感染。
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1361-5. doi: 10.1073/pnas.94.4.1361.
10
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