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麻疹病毒的极化出芽并非由病毒表面糖蛋白所决定。

Polarized budding of measles virus is not determined by viral surface glycoproteins.

作者信息

Maisner A, Klenk H, Herrler G

机构信息

Institut für Virologie, Philipps-Universität Marburg, 35037 Marburg, Germany.

出版信息

J Virol. 1998 Jun;72(6):5276-8. doi: 10.1128/JVI.72.6.5276-5278.1998.

Abstract

For viruses that mature by a budding process, the envelope glycoproteins are considered the major determinants for the site of virus release from polarized epithelial cells. Viruses are usually released from that membrane domain where the viral surface glycoproteins are transported to. We here report that measles virus has developed a different maturation strategy. Measles virus was found to be released from the apical membrane domain of polarized epithelial cells, though the surface glycoproteins H and F were transported in a nonpolarized fashion and to the basolateral membrane domain, respectively.

摘要

对于通过出芽过程成熟的病毒,包膜糖蛋白被认为是病毒从极化上皮细胞释放部位的主要决定因素。病毒通常从病毒表面糖蛋白被转运至的那个膜结构域释放。我们在此报告,麻疹病毒已形成了一种不同的成熟策略。尽管表面糖蛋白H和F分别以非极化方式转运至基底外侧膜结构域,但发现麻疹病毒是从极化上皮细胞的顶端膜结构域释放的。

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本文引用的文献

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Virus infection of polarized epithelial cells.极化上皮细胞的病毒感染。
Adv Virus Res. 1993;42:187-247. doi: 10.1016/s0065-3527(08)60086-x.
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Cytochalasin B inhibits the maturation of measles virus.细胞松弛素B抑制麻疹病毒的成熟。
Virology. 1983 Jan 15;124(1):59-74. doi: 10.1016/0042-6822(83)90290-8.

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