[抗肿瘤制剂威派西德的肝毒性作用机制]
[The mechanisms of the hepatotoxic action of the antitumor preparation vepesid].
作者信息
Vetoshkina T V, Dubskaia T Iu, Timina E A, Gol'dberg V E
机构信息
Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
出版信息
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):54-6.
PMID:9575414
Abstract
It was shown in experiments on rats that intravenous infusion of the antitumor drug vepesid in a maximum tolerated dose causes stimulation of free-radical oxidation and changes in the fractional composition of lipids and phospholipids in the hepatic tissue. Changes in the activity of aminotransferases and alkaline phosphatase in the blood were recorded.
摘要
在对大鼠的实验中发现，以最大耐受剂量静脉输注抗肿瘤药物依托泊苷会刺激自由基氧化，并导致肝组织中脂质和磷脂的组成成分发生变化。还记录了血液中氨基转移酶和碱性磷酸酶活性的变化。
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