Kumar R, Fidler I J
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
In Vivo. 1998 Jan-Feb;12(1):27-34.
The progressive growth of primary neoplasms and metastases depends on the development of adequate vasculature, i.e., angiogenesis. The extent of vascularization in different malignancies correlates directly with their metastatic potential and, hence, inversely with the survival of the patient. The induction of neovascularization is mediated by both tumor cells and host cells and the interaction of the two. The balance of positive and negative regulatory molecules released by tumor cells and host cells determines the biological outcome which, in the case of tumor growth, favors angiogenesis.
原发性肿瘤和转移灶的渐进性生长依赖于充足脉管系统的形成，即血管生成。不同恶性肿瘤中的血管化程度与其转移潜能直接相关，因此与患者的生存率呈负相关。新生血管形成的诱导由肿瘤细胞、宿主细胞以及两者之间的相互作用介导。肿瘤细胞和宿主细胞释放的正负调节分子的平衡决定了生物学结果，就肿瘤生长而言，这有利于血管生成。
