Hirose K, Hamajima N, Takezaki T, Kuroishi T, Kuzuya K, Sasaki S, Tokudome S, Tajima K
Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
J Epidemiol. 1998 Mar;8(1):6-14. doi: 10.2188/jea.8.6.
The importance of the major risk and protective factors for cervical cancer in women by age group was evaluated with the use of data from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. This study included 416 cervical cancer cases and 20,985 referents confirmed as free of cancer. Cases and referents were divided into three age groups: the younger, middle and older age groups (30-44, 45-54 and 55-69 years old, respectively). Logistic model was applied separately to the three groups to estimate odds ratios (ORs) of smoking, beverage and dietary habits with adjustment for marital and reproductive factors. The elevated OR of current smokers was observed consistently in all age groups, while alcohol intake did not show any increased ORs. Dietary control for health lowered ORs for all three age groups, and the effect appeared to be more pronounced among the older age group (OR = 0.49, 95% confidence interval: 0.30-0.80). Higher frequency intake of green-yellow vegetables consistently afforded lower ORs among all three age groups. This risk increment of smoking and risk reduction by dietary control were consistent in all age groups. These findings suggested practicable prevention strategy for the cervical cancer by modifying general life style.
利用日本爱知癌症中心医院流行病学研究项目（HERPACC）的数据，评估了按年龄组划分的女性宫颈癌主要风险和保护因素的重要性。本研究纳入了416例宫颈癌病例和20985名经确认无癌症的对照对象。病例和对照对象被分为三个年龄组：年轻、中年和老年组（分别为30 - 44岁、45 - 54岁和55 - 69岁）。对这三组分别应用逻辑模型，以估计吸烟、饮料和饮食习惯的优势比（OR），并对婚姻和生殖因素进行调整。在所有年龄组中均一致观察到当前吸烟者的OR升高，而饮酒并未显示出任何OR升高。为健康进行饮食控制降低了所有三个年龄组的OR，且这种效果在老年组中似乎更为明显（OR = 0.49，95%置信区间：0.30 - 0.80）。在所有三个年龄组中，较高频率摄入黄绿色蔬菜始终具有较低的OR。吸烟导致的风险增加和饮食控制带来的风险降低在所有年龄组中都是一致的。这些发现表明，通过改变一般生活方式可以制定切实可行的宫颈癌预防策略。
