Tajima K, Hirose K, Ogawa H, Yoshida M, Ohta M
Div. of Epidemiology, Aichi Cancer Center.
Gan No Rinsho. 1990 Feb;Spec No:351-64.
To promote the comprehensive measure of cancer prevention for future, a hospital-based epidemiological study on a large scale has started at the Aichi Cancer Center Hospital. As the first step of this study by using a common questionnaire, a simultaneous case-control study on the two cancers involving 175 cases with breast cancer, 56 cases with cervical cancer and 231 controls was conducted in 1988. Body weight was positively related to breast cancer only in older (50-69) patients. Young age at first birth (less than or equal to 23) increased the risk of cervical cancer (OR = 4.1). Active and passive smoking increased the risk of cervical cancer (OR = 2.6, 2.3) but only passive smoking increased the risk of older breast cancer (OR = 2.0). Frequent intakes of green vegetables and carrot decreased the risk of younger (30-49) breast cancer (OR = 0.5, 0.5) and cervical cancer (OR = 0.3, 0.5). Some other factors with positive and negative effects on these two cancers were identified in this case-control analysis.
为推动未来癌症预防综合措施的实施，爱知癌症中心医院已启动一项大规模的基于医院的流行病学研究。作为本研究的第一步，1988年采用通用问卷对175例乳腺癌患者、56例宫颈癌患者及231名对照者进行了这两种癌症的同步病例对照研究。仅在年龄较大（50 - 69岁）的患者中，体重与乳腺癌呈正相关。初产年龄较小（小于或等于23岁）会增加患宫颈癌的风险（比值比=4.1）。主动和被动吸烟都会增加患宫颈癌的风险（比值比分别为2.6、2.3），但只有被动吸烟会增加年龄较大患者患乳腺癌的风险（比值比=2.0）。经常食用绿色蔬菜和胡萝卜会降低年龄较小（30 - 49岁）患者患乳腺癌（比值比=0.5、0.5）和宫颈癌（比值比=0.3、0.5）的风险。在本次病例对照分析中还确定了其他一些对这两种癌症有正负影响的因素。
