Tikhonov Iu V, Markusheva L I, Toguzov R T
Klin Lab Diagn. 1998 Mar(3):3-6.
The pool of free purine derivatives and activities of the key enzymes of purine metabolism (adenosine deaminase, purine nucleoside phosphorylase, and 5'-nucleotidase) in lymphocytes, erythrocytes, and epidermis homogenates were measured in 20 normal subjects and 15 patients with psoriasis by high-performance liquid chromatography. The levels of AMP, GMP, and IMP purine monophosphates are decreased in the epidermis and red cells of psoriasis patients, whereas the final products of hypoxanthine, xanthine, and uric acid metabolism are accumulating, and the activities of ADA and PNP are increased double in the skin, all this indicating purine derivatives catabolism.
通过高效液相色谱法测定了20名正常受试者和15名银屑病患者淋巴细胞、红细胞及表皮匀浆中游离嘌呤衍生物池以及嘌呤代谢关键酶（腺苷脱氨酶、嘌呤核苷磷酸化酶和5'-核苷酸酶）的活性。银屑病患者表皮和红细胞中AMP、GMP和IMP嘌呤单磷酸水平降低，而次黄嘌呤、黄嘌呤和尿酸代谢的终产物在蓄积，且皮肤中ADA和PNP的活性增加了一倍，所有这些均表明嘌呤衍生物的分解代谢。
