Trubnikov G A, Sukharev A E, Uklistaia T A, Orlova E A
Klin Med (Mosk). 1998;76(3):21-6.
Immunochemical tests of blood sera from 160 healthy residents of the town of Astrakhan were performed to determine standard quantities of ferritin and lactoferrin in the serum. Examinations of the saliva from 280 healthy subjects provided the frequency of occurrence and levels of excretory lactoferrin. These iron-containing proteins were also assessed in different biosubstrates (blood serum, sputum, saliva, pleural fluid, lung tissues) from 550 patients with benign and malignant lesions of the lungs and pleura. Tests for ferritin and lactoferrin proved useful in evaluation of bronchopulmonary inflammation activity, early detection of pulmonary and intrapleural supputation, differential diagnosis of chronic nonspecific pulmonary diseases and lung cancer. The excretory salivary lactoferrin provided sufficient information on the condition of adaptive mechanisms of local defense of the lungs in premorbid state in 420 workers of the gas-processing plant exposed to aggressive occupational pollutants.
对160名阿斯特拉罕市健康居民的血清进行免疫化学检测，以确定血清中铁蛋白和乳铁蛋白的标准含量。对280名健康受试者的唾液进行检测，得出排泄性乳铁蛋白的出现频率和水平。还对550例肺部和胸膜良性及恶性病变患者的不同生物基质（血清、痰液、唾液、胸水、肺组织）中的这些含铁蛋白质进行了评估。铁蛋白和乳铁蛋白检测被证明有助于评估支气管肺部炎症活动、早期发现肺部和胸膜内化脓、慢性非特异性肺部疾病和肺癌的鉴别诊断。排泄性唾液乳铁蛋白为420名接触有害职业污染物的天然气加工厂工人在病前状态下肺部局部防御适应机制的状况提供了充分信息。
