Nishikawa M, Suzuki S, Miyazawa N, Suzuki Y, Numata M, Komatsu S, Rin M, Yamamoto N, Okubo T
The First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
J Asthma. 1998;35(2):219-24. doi: 10.3109/02770909809068210.
We measured the serum level of eosinophil cationic protein (ECP), determined the blood eosinophil count, and assessed pulmonary function by spirometry and airway responsiveness to methacholine in 80 patients with a cough lasting longer than 3 weeks without an obvious cause. The serum level of ECP was above the cutoff value of 15.7 ng/mL (mean + 2 SD in 105 healthy control adults) in 30 (37.5%) of 80 patients (high-serum-ECP group). The blood eosinophil count was significantly higher in the high-serum-ECP group than in the normal-serum-ECP group (p < 0.01). The cumulative dose of methacholine causing a 35% decrease in respiratory conductance (PD35Grs) was significantly lower in the high-serum-ECP group than in the normal-serum-ECP group (p < 0.001). The serum concentration of ECP was correlated with the blood eosinophil count and the PD35Grs (r = 0.59, p < 0.001 and r = -0.48, p < 0.001, respectively). These findings suggest a possible role for serum level of ECP in management of patients with chronic cough.
我们对80例持续咳嗽超过3周且无明显病因的患者，测定了血清嗜酸性粒细胞阳离子蛋白（ECP）水平，检测了血液嗜酸性粒细胞计数，并通过肺活量测定法和对乙酰甲胆碱的气道反应性评估了肺功能。80例患者中有30例（37.5%）的血清ECP水平高于15.7 ng/mL的临界值（105名健康对照成年人的均值 + 2标准差）（高血清ECP组）。高血清ECP组的血液嗜酸性粒细胞计数显著高于正常血清ECP组（p < 0.01）。高血清ECP组引起呼吸传导率下降35%的乙酰甲胆碱累积剂量（PD35Grs）显著低于正常血清ECP组（p < 0.001）。血清ECP浓度与血液嗜酸性粒细胞计数及PD35Grs相关（r分别为0.59，p < 0.001和r = -0.48，p < 0.001）。这些发现提示血清ECP水平在慢性咳嗽患者的管理中可能发挥作用。
