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一种用于评估贫血的廉价且可靠的新型血红蛋白比色计。

An inexpensive and reliable new haemoglobin colour scale for assessing anaemia.

作者信息

Lewis S M, Stott G J, Wynn K J

机构信息

Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

出版信息

J Clin Pathol. 1998 Jan;51(1):21-4. doi: 10.1136/jcp.51.1.21.

Abstract

AIM

To describe a new inexpensive method (the WHO Colour Scale) for estimating haemoglobin concentration from a drop of blood by means of a colour scale, and to compare its reliability with a standard laboratory method of measuring haemoglobin, and its clinical usefulness in field trials.

METHODS

The new colour scale method was used to measure haemoglobin concentration in 1213 random venous blood samples from routine work in four laboratories (one each in the UK, South Africa, Thailand, and Switzerland). Limited field trials of the method for assessing clinical usefulness were done in a rural hospital (in South Africa) staffed by nurses, at two blood donor sessions (one each in South Africa and Thailand), and by nonlaboratory personnel in malaria clinics (in Thailand), following training and a short practice session.

RESULTS

In the laboratory based comparability study the presence of anaemia was reliably detected using the new method with 91% sensitivity and 86% specificity. Clinically relevant levels of anaemia (mild to moderate, pronounced, and severe) were graded and serious anaemia (< 8 g/dl) was identified with an efficiency of 89%. The clinical trials showed the ease and reliability with which the colour scale could be used by non-laboratory persons after brief training. The blood donor trials showed it to be at least as reliable as the copper sulphate method with the advantage of being more convenient.

CONCLUSIONS

The preliminary studies have shown that the WHO Colour Scale is a reliable screening method for detecting anaemia, especially for diagnosing serious anaemia. Following a brief training session health workers found it simple to use and, at a cost of about 1/10th that for traditional photometric analysis, it should be of value in "countries in need" for primary health centres, obstetrical management, paediatric clinics, tropical disease control programmes, blood transfusion donor selection, as well as for industrial health checks and epidemiological studies.

摘要

目的

描述一种新的低成本方法(世界卫生组织颜色标尺法),通过颜色标尺利用一滴血估算血红蛋白浓度,并将其可靠性与测量血红蛋白的标准实验室方法进行比较,以及评估其在现场试验中的临床实用性。

方法

采用新的颜色标尺法对来自四个实验室(英国、南非、泰国和瑞士各一个)日常工作的1213份随机静脉血样本测量血红蛋白浓度。在一家由护士工作的农村医院(南非)、两次献血活动(南非和泰国各一次)以及疟疾诊所(泰国)由非实验室人员进行了该方法临床实用性评估的有限现场试验,试验前进行了培训和简短的练习。

结果

在基于实验室的可比性研究中,使用新方法能可靠地检测出贫血,灵敏度为91%,特异性为86%。对临床相关贫血水平(轻度至中度、重度和极重度)进行了分级,识别严重贫血(<8g/dl)的效率为89%。临床试验表明,经过简短培训后非实验室人员使用颜色标尺既简便又可靠。献血者试验表明,该方法至少与硫酸铜法一样可靠,且更方便。

结论

初步研究表明,世界卫生组织颜色标尺法是检测贫血尤其是诊断严重贫血的可靠筛查方法。经过简短培训,卫生工作者发现该方法易于使用,且成本约为传统光度分析的十分之一,对于“有需要的国家"的初级卫生保健中心、产科管理、儿科诊所、热带病控制项目、输血献血者选择以及工业健康检查和流行病学研究应具有价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b88/500425/d302d0009579/jclinpath00262-0031-a.jpg

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