Nada T, Moriyasu F, Kono Y, Matsumura T
Kurashiki Central Hospital.
Nihon Rinsho. 1998 Apr;56(4):980-4.
Intravenously injected ultrasonic contrast agents have improved sonographic visualization of blood flow. On enhanced color Doppler sonography using Levovist (Schering AG, Germany) and FS069 (Molecular Biosystems, USA), minute tumor blood flow in woodchuck hepatoma was clearly demonstrated as vascular flow around and within the tumors. Furthermore, on enhanced gray scale sonography using FS069, parenchymal flow was demonstrated as sonographic "tumor stain". However, larger doses of the agent provided shadowing that disturbed sonographic evaluation of deeper portions of the liver. With advances of second harmonic imaging, it may be possible to evaluate only blood perfusion in that it eliminates the signals of fundamental frequency.
静脉注射超声造影剂可改善超声对血流的可视化。在使用Levovist（德国先灵公司）和FS069（美国分子生物系统公司）进行增强彩色多普勒超声检查时，土拨鼠肝癌中的微小肿瘤血流可清晰显示为肿瘤周围和内部的血管血流。此外，在使用FS069进行增强灰阶超声检查时，实质血流表现为超声“肿瘤染色”。然而，较大剂量的造影剂会产生声影，干扰对肝脏深部的超声评估。随着二次谐波成像技术的进步，有可能仅评估血液灌注情况，因为它可消除基频信号。
