Chernitsa O I, Togo A V, Shutkin V A, Khanson K P, Imianitov E N
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Vopr Onkol. 1998;44(1):33-6.
Race is widely believed to be a factor in the relationship between S allele of L-MYC oncogene and disseminated lung cancer. In particular, the clinical significance of L-MYC genotype was demonstrated in the Japanese while the results for the white US, Australian and Norwegian cohorts were negative. The present study was concerned with distribution of L-MYC oncogene alleles in 43 patients with lung cancer and 77 healthy subjects in Moldova. L and S allele frequency in both groups were nearly identical. However, the SS genotype was registered much more frequently in patients with metastasis (10/28; 36%)(p < 0.05) than in those with localized tumor (0/12). Moreover, overall frequency of S allele was significantly higher in lung cancer patients with node involvement (35/56; 63%)(p < 0.02) than in those with localized tumors (8/24; 33%)(p < 0.02). Finally, a significant correlation was found between S allele occurrence and distant metastases (M1: 19/28; 68%; M0:26/58; 45%)(p < 0.05). Similar data were reported in Russia. (ABSTRACT TRUNCATED)
种族被广泛认为是L-MYC癌基因S等位基因与播散性肺癌之间关系的一个因素。特别是，L-MYC基因型的临床意义在日本人中得到了证实，而美国白人、澳大利亚人和挪威人群的研究结果为阴性。本研究关注的是摩尔多瓦43例肺癌患者和77例健康受试者中L-MYC癌基因等位基因的分布。两组的L和S等位基因频率几乎相同。然而，转移患者中SS基因型的登记频率（10/28；36%）（p<0.05）比局限性肿瘤患者（0/12）高得多。此外，有淋巴结受累的肺癌患者中S等位基因的总体频率（35/56；63%）（p<0.02）显著高于局限性肿瘤患者（8/24；33%）（p<0.02）。最后，发现S等位基因出现与远处转移之间存在显著相关性（M1：19/28；68%；M0：26/58；45%）（p<0.05）。俄罗斯也报道了类似的数据。（摘要截断）
