Fecik R A, Frank K E, Gentry E J, Menon S R, Mitscher L A, Telikepalli H
Department of Medicinal Chemistry, Kansas University, Lawrence 66045-2506, USA.
Med Res Rev. 1998 May;18(3):149-85. doi: 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x.
The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.
对组合化学文献进行了综述，特别关注在设计和评估含有类药物分子的文库时对吸收、分布、代谢和排泄的考量。尤其对已发表的文库进行评估，以确定其产物具有口服生物利用度的可能性。
