Horton Douglas A, Bourne Gregory T, Smythe Mark L
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, 4072, Qld., Australia.
J Comput Aided Mol Des. 2002 May-Jun;16(5-6):415-30. doi: 10.1023/a:1020863921840.
Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.
据报道，头对尾环肽能以高亲和力与多种不相关的受体类别结合。因此，它们可被视为优势结构。本综述概述了在组合文库中合成大环环肽以及环二肽或二酮哌嗪的策略。还简要概述了这些分子的一些生物学应用，从而证明将它们纳入优势结构是合理的。
