Semenzato G, Amadori G, Basso G, Cocito M G, Colombatti M, Anglani F, Gasparotto G
University of Padua Medical School, Department of Medicine, Italy.
J Clin Lab Immunol. 1979 Apr;2(1):45-50.
Peripheral blood lymphocytes from a patient with chronic lymphocytic leukaemia of T cell origin were studied. The thymus derived nature of these lymphocytes was confirmed by surface markers, mitogen cultures, mixed lymphocyte reaction, cytotoxicity studies, and cytochemical stains. This case is notable for several clinical and laboratory findings. Among these, the benign clinical course, the reduced rate of serum immunoglobulins, the elevated number of active E rosettes, the increased PHA-induced response to low mitogen doses, the absence of PHA mediated cellular cytotoxicity, and the thy-like positivity to ANAE should be pointed out. Emphasis should be placed, however, on the loss of stimulatory ability in MLR. This last feature supports the hypothesis that these cells proliferate as a clone.
对一名T细胞起源的慢性淋巴细胞白血病患者的外周血淋巴细胞进行了研究。这些淋巴细胞的胸腺来源性质通过表面标志物、丝裂原培养、混合淋巴细胞反应、细胞毒性研究和细胞化学染色得以证实。该病例有几个临床和实验室发现值得注意。其中，良性临床病程、血清免疫球蛋白水平降低、活性E花环数量增加、对低丝裂原剂量的PHA诱导反应增强、PHA介导的细胞毒性缺失以及对ANAE呈甲状腺样阳性应予以指出。然而，应强调的是混合淋巴细胞反应中刺激能力的丧失。这最后一个特征支持了这些细胞作为一个克隆进行增殖的假说。
