一些约旦药用植物提取物的抗伤害感受和抗炎作用。

Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts.

作者信息

Atta A H, Alkofahi A

机构信息

Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid.

出版信息

J Ethnopharmacol. 1998 Mar;60(2):117-24. doi: 10.1016/s0378-8741(97)00137-2.

DOI:10.1016/s0378-8741(97)00137-2

PMID:9582001

Abstract

The anti-nociceptive effect of ethanolic extract of 11 traditionally used Jordanian plants was studied by using the acetic acid-induced writhing and hot-plate test in mice. The anti-inflammatory effect of these plants was determined by xylene-induced ear oedema in mice and cotton pellet granuloma test in rats. Mentha piperita, Cinnamomum zeylanicum, Apium graveolens, Eucalyptus camaldulentis, and Ruta graveolens possess an anti-nociceptive effect against both acetic acid-induced writhing and hot plate-induced thermal stimulation. M. piperita, Jasminum officinale, Commiphora molmol, and Beta vulgaris possess an anti-inflammatory effect against acute (xylene-induced ear oedema) and chronic (cotton-pellet granuloma) inflammation. The anti-nociceptive and anti-inflammatory effects were dose dependent. These data affirm the traditional use of some of these plants for painful and inflammatory conditions.

摘要

通过在小鼠中使用乙酸诱导扭体试验和热板试验，研究了11种传统使用的约旦植物乙醇提取物的抗伤害感受作用。通过二甲苯诱导的小鼠耳肿胀试验和大鼠棉球肉芽肿试验来测定这些植物的抗炎作用。薄荷、锡兰肉桂、芹菜、桉和芸香对乙酸诱导的扭体和热板诱导的热刺激均具有抗伤害感受作用。薄荷、素馨、没药和甜菜对急性（二甲苯诱导的耳肿胀）和慢性（棉球肉芽肿）炎症均具有抗炎作用。抗伤害感受和抗炎作用均呈剂量依赖性。这些数据证实了其中一些植物在治疗疼痛和炎症方面的传统用途。