Gordon G G, Altman K, Southren A L, Rubin E, Lieber C S
N Engl J Med. 1976 Oct 7;295(15):793-7. doi: 10.1056/NEJM197610072951501.
To determine whether ethanol per se affects testosterone metabolism, alcohol was administered to normal male volunteers for periods up to four weeks, resulting in an initial dampening of the episodic bursts of testosterone secretion followed by decreases in both the mean plasma concentration and the production rate of testosterone. The volunteers received adequate nutrition and none lost weight during the study, which tended to exclude a nutritional disturbance as the cause of the decreased testosterone levels. The changes in plasma luteinizing hormone suggested both a central (hypothalamus-pituitary) and gonadal effect of alcohol. In addition, alcohol consumption increased the metabolic clearance rate of testosterone in most subjects studied, probably owing to the combined effects of a decreased plasma binding capacity for the androgen and increased hepatic testosterone A-ring reductase activity. These results indicate that alcohol markedly affects testosterone metabolism independently of cirrhosis or nutritional factors.
为了确定乙醇本身是否会影响睾酮代谢，对正常男性志愿者给予酒精长达四周，结果导致睾酮分泌的阵发性脉冲最初受到抑制，随后血浆睾酮平均浓度和睾酮生成率均下降。志愿者在研究期间获得了充足的营养，且体重均未减轻，这倾向于排除营养紊乱是睾酮水平降低的原因。血浆促黄体生成素的变化表明酒精对中枢（下丘脑 - 垂体）和性腺均有影响。此外，在大多数研究对象中，饮酒增加了睾酮的代谢清除率，这可能是由于雄激素的血浆结合能力下降和肝脏睾酮A环还原酶活性增加的综合作用。这些结果表明，酒精显著影响睾酮代谢，与肝硬化或营养因素无关。
