Serov V V
I. M. Sechenov Moscow Medical Academy.
Arkh Patol. 1998 Jan-Feb;60(1):23-7.
Senile amyloidosis can be systemic (generalized) or local, this being determined by the protein precursor of the amyloid fibrils. Systemic cardiovascular amyloidosis should be distinguished from AL-amyloidosis. Senile amyloidosis is represented by both endocrine and nonendocrine forms. Endocrine forms include isolated auricular amyloidosis and amyloidosis of the Langerhans islands, while non-endocrine forms include aortic amyloidosis, cerebral amyloidosis, eye amyloidosis and amyloidosis of the prostate and/or seminal vesicles. Most frequent are combinations of the endocrine with aortic amyloidosis or Langerhand island amyloidosis with cerebral amyloidosis and eye amyloidosis. These data reject the Schwarts tetrad as necessary manifestation of senility.
老年淀粉样变性可为全身性（广泛性）或局限性，这取决于淀粉样纤维的蛋白质前体。全身性心血管淀粉样变性应与AL型淀粉样变性相鉴别。老年淀粉样变性有内分泌和非内分泌两种形式。内分泌形式包括孤立性心房淀粉样变性和胰岛淀粉样变性，而非内分泌形式包括主动脉淀粉样变性、脑淀粉样变性、眼淀粉样变性以及前列腺和/或精囊淀粉样变性。最常见的是内分泌型与主动脉淀粉样变性的组合，或胰岛淀粉样变性与脑淀粉样变性和眼淀粉样变性的组合。这些数据否定了施瓦茨四联症是衰老的必然表现这一观点。
