Yamawaki S, Kagaya A, Tawara Y, Inagaki M
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Life Sci. 1998;62(17-18):1665-70. doi: 10.1016/s0024-3205(98)00125-8.
In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.
在本文中，基于我们最近的研究工作，我们展示了细胞内钙（Ca2+）信号系统在情绪障碍病理生理学中的重要性。情感障碍患者在对血清素作出反应时，细胞内Ca2+似乎有增强的升高。我们观察了抗抑郁药物对大鼠培养神经元细胞和胶质瘤细胞内Ca2+信号的影响，发现急性应用几类抗抑郁药物可抑制细胞内Ca2+信号和与Ca2+相关的信号。研究细胞内Ca2+信号系统的作用对于理解情感障碍的病理生理学很重要。
