Kami K, Senba E
Department of Health Science, Osaka University of Health and Sport Sciences, Japan.
Muscle Nerve. 1998 Jun;21(6):819-22. doi: 10.1002/(sici)1097-4598(199806)21:6<819::aid-mus20>3.0.co;2-m.
In the present study, we characterized both temporal and spatial expression patterns of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) messenger ribonucleic acids (mRNAs) in injured skeletal muscle using in situ hybridization. LIF and IL-6 mRNAs were expressed in mononucleated cells and damaged muscle cells. Further, signals for LIF mRNA were also detected in Schwann cell-like cells of intramuscular nerves. These results suggest that the earliest events involved in the repair of injured muscles and nerves may be triggered by these cytokines.
在本研究中，我们利用原位杂交技术对白血病抑制因子（LIF）和白细胞介素-6（IL-6）信使核糖核酸（mRNA）在损伤骨骼肌中的时空表达模式进行了表征。LIF和IL-6 mRNA在单核细胞和受损肌细胞中表达。此外，在肌内神经的雪旺氏细胞样细胞中也检测到了LIF mRNA的信号。这些结果表明，这些细胞因子可能触发损伤肌肉和神经修复过程中涉及的最早事件。
