Fitzgerald D J
Environmental Health Branch, South Australian Health Commission, Adelaide, Australia.
Am J Clin Nutr. 1998 May;67(5 Suppl):1098S-1102S. doi: 10.1093/ajcn/67.5.1098S.
It is important for public health authorities to set a scientifically sound guideline value for the safe ingestion of copper in drinking water. To date, the principal health-based guideline values have been set by the US Environmental Protection Agency (1.3 mg Cu/L) and the World Health Organization (2.0 mg Cu/L). However, close examination of the data and assumptions used in the derivation of these values reveals a paucity of scientifically defensible information. Several international groups are now reviewing this issue, and others have begun epidemiologic studies that may provide useful copper exposure and toxicity data. Investigations of acute copper toxicity in human populations are most likely to affect future revisions of the guideline value for copper in drinking water.
对于公共卫生当局而言,为饮用水中铜的安全摄入量设定科学合理的指导值至关重要。迄今为止,主要基于健康的指导值已由美国环境保护局(1.3毫克铜/升)和世界卫生组织(2.0毫克铜/升)设定。然而,仔细审查这些值推导过程中所使用的数据和假设会发现,缺乏科学上站得住脚的信息。几个国际组织目前正在审查这个问题,其他组织也已开始进行流行病学研究,这些研究可能会提供有用的铜暴露和毒性数据。对人群急性铜毒性的调查最有可能影响未来饮用水中铜指导值的修订。